Codeine is noted to point out no proof of carcinogenicity or mutagenicity in a variety of exam systems, such as the micronucleus and sperm abnormality assays and the Salmonella assay. Promethazine was nonmutagenic during the Salmonella take a look at system of Ames.promethazine decreases effects of pitolisant by Other (see comment). Steer clear of